What is ICSI?

ICSI is a short acronym on Intracytoplasmic Sperm Injection. ICSI is an Assisted Reproduction Technology (ART), procedure that integrates a healthy sperm cell, directly into the mature egg cell, in vitro condition. The use of surgical injection tool, favours fusion of sperm cell with mature egg to achieve fertilization.

What is ICSI?

The glass micro-pipette, collects a single-sperm isolated on culture medium, to lead a fusion at egg-cytoplasm. The mechanical-piercing of egg-cell wall, to reach egg-cell-mass, at the inner-loci of the oocyte; is followed by the release of isolated sperm cell. The oocyte is cultured & incubated on media plates, to reach fertilization, as end-result from ICSI procedure. ICSI, is primarily used in InVitro condition, to treat male-infertility. The secondary treatment population, includes, infertile males, not able to achieve a penetration of sperm into egg. The technique is employed as selective measure, to achieve fertilization, in case of sperm donation. The ICSI is performed as a complimentary step, to oocyte-retrieval from egg donor. The failure at fertilization, on account of inability of sperm cell, to penetrate the cell-wall of mature eggs, is curated, with Intracytoplasmic sperm injection or ICSI.

Washed or unwashed sperm cells are primed into retrieved-oocyte, in outside body conditions, in lab environment in ICSI technique. The use of bio-markers, in embryology studies, has generated false-alarm or higher false positive rate. The use of hormonal supplements for progesterone hormone in luteal support, improves success rate in ICSI cycles. The DNA fragmentation bears an impact at the success rate in ICSI procedure. There is a myth about birth defects arising in off-spring, from the use of ICSI technique, in child, born from the technique.

The present studies do-not link the inheritance of birth-defects with ICSI technique. The transfer of Hepatitis-B infection from carrier-female, to the off-spring, through ICSI technique, is another concern that can be avoided through PGD step to clean or sterilize germ-plasm from genetic traits.

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Dr Rita Bakshi

Dr. Rita Bakshi is a well renowned gynaecologsts and obstetrician with a rich experience of more than 20 years in the field of Assisted Reproductive technology (ART). Dr. Rita has extensive experience in all fields of assisted conception, with a special interest in IVF and Egg Donor Surrogacy. She’s also the founder of ADIVA group of Hospitals. During the past two decades of service, Dr. Rita Bakshi has brought happiness to thousands of couples and performed over 6000 caesarean sections, 3000 Hysterectomies, 1000 cases of IVF annually with a success rate of over 45%. She takes your dreams seriously and focuses on the long term and best interests of the child, the surrogate and the intended parent(s).