Mild IVF Cycle And Protocol  

The light or modified natural cycle in vitro fertilization is performed during the woman’s natural menstrual cycle, and later fertility drugs are added to help stimulate the ovaries to produce a large number of eggs to be laid. This treatment is sometimes called Mini IVF.

IVF in the natural cycle is related to many difficulties related to the quality of oocytes obtained during puncture. Only one (in some cases, two) follicular characteristics in a natural menstrual cycle can exacerbate this situation.

In the absence of contraindications, to improve effectiveness, use the IVF program of hormone-containing drugs in the natural cycle. The medication slightly affects the maturation of the eggs and prevents spontaneous ovulation.

Mild IVF

The next development of natural IVF is now moving towards women with mild drug stimulation because the possible side effects of stimulation drugs are reduced. The goal is to collect 2 to 7 eggs, and in “regular” IVF, we will try to obtain as many eggs as safely as possible, usually eight or more.

Mild IVF cycle Success amount

Success amounts are strenuous to predict because they largely depend on the relative strength of the medicine regimen used, but as common sense implies, they are somewhere between “natural” and “conventional” treatments.

Protocol diagrams

The following types of agreements exist in the natural cycle, and their plans differ in the degree of medicine exposure:

• Pure natural cycle-no need for manual intervention in the maturation process of oocytes.
• The modified natural circulation. Improve the quality of eggs obtained.
• Revised the IVF protocol in the natural cycle.

Outline of the IVF protocol in the “pure” natural cycle:

• Start follicle determination from 7-8 days-monitor the growth of follicles;
• When the follicle diameter reaches 15-16 mm, the LH level will be monitored in the laboratory. To do this, donate blood for analysis (several times a day) or perform an ovulation test.
• The puncture should be performed no later than 24 hours after LH is positive.

IVF protocol diagram in the modified natural cycle:

• Follicle determination is performed from 7-8 days.
• When the average diameter of the follicle reaches 17–18 mm, hCG is injected into the body to simulate what happens during the peak of LH. This promotes the maturation of the eggs.
• Aspirate follicular fluid 28-34 hours after hCG injection.
• This approach increases the chance of obtaining mature oocytes, but natural ovulation is possible. To prevent the premature release of eggs, the following scheme has been developed.

Scheme of the modified IVF natural cycle protocol:

• Follicle determination is performed from 7-8 days.
• From the day the follicle reaches 15 mm, GnRH antagonists (the drug that can block the synthesis of LH-prevent spontaneous ovulation) and FSH drugs (administered for 2-3 days, mature under the action of the follicle).
• When the dominant follicle reaches an average diameter of 18 mm, hCG is given
• 30–34 hours later-aspirate the contents of the follicle.

This operations sequence allows you to intervene in the maturation process and obtain the greatest possibility of obtaining mature oocytes.